As a group, the Pagans' illegal activities usually involve narcotics (methamphetamines) and chop shops. Individually, members and associates often engage in a variety of other illegal conduct such as assault, weapon possession, sex crimes and fraud. The latter activities are done for the individual's benefit and not the group. Generally, profits from illegal activities sanctioned by the Mother Club require a 10% "contribution" from the local chapter.

The Pagans have a following of associates who, for various reasons, elect not to seek membership. Often, the relationship between the member and associate has its basis in a mutually beneficial venture, usually of an illicit nature. A case in point was the association between Roland Kownacki of Atlantic City and the Pagans. Kownacki, a convicted drug dealer, served the Pagans' purposes as a "chemist" or "cooker" in the production of methamphetamine. Other examples of symbiotic relationships can readily be found in the activities typically associated with outlaw biker groups, including chop shops, bars, tattoo parlors, narcotics distribution and firearms trafficking.

There is also evidence that the Pagans have maintained a working relationship with the LCN. Prior to the decline of the Scarfo organization, there were instances of both cooperation and conflict between the two groups, most notably in the area of narcotics. Cooperation existed as a result of the Scarfo group's access to P2P, a necessary chemical precursor in the production of methamphetamine. However, conflict surfaced when members of Scarfo's crew robbed Kownacki, who was part owner of a jewelry store, of gold and cash. In retaliation, the Pagans apparently aligned themselves with an outcast faction of the then-warring Scarfo mob. Such alliances and conflicts appear to be a thing of the past. With changes occurring in both groups and the absence of a mutually beneficial illegal activity, there does not appear to be a need or desire for this association to continue.